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Online Monitoring Solution for Bioprocess Exhaust Gas | Shanghai Gaochuan Electronics Debuts at BIOCHINA Bioprocessing Exhibition
Release time：
2026-09-29
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Summary
As the industrialization of synthetic biology accelerates, the demand for digital control in fermentation processes continues to grow across biopharmaceuticals, bio-based materials, and biological fermentation industries. Process Analytical Technology (PAT) has become a key tool for improving quality, efficiency, and process stability in biomanufacturing facilities. Online monitoring of oxygen (O₂) and carbon dioxide (CO₂) in fermentation off-gas is a critical step for obtaining microbial metabolic data and calculating key parameters such as oxygen uptake rate (OUR), carbon dioxide evolution rate (CER), and respiratory quotient (RQ). At the 17th BIOCHINA International Exhibition on Biopharmaceutical Fermentation Products and Equipment, Shanghai Gaochuan Instruments Co., Ltd. showcased its online fermentation off-gas analysis system and series of oxygen analyzers, presenting a complete domestic solution for gas monitoring in fermentation processes to customers in biological fermentation, synthetic biology, and cell culture.
During R&D and large-scale production of fermentation processes, relying solely on single-point parameters such as dissolved oxygen and pH often fails to fully reflect actual microbial metabolism. Offline sampling introduces delays and carries risks of contamination, making it unsuitable for continuous, intelligent manufacturing in modern biotech facilities. By installing online gas analyzers in the off-gas lines of fermenters, real-time measurements of O₂ and CO₂ concentrations can be continuously collected, enabling instant calculation of OUR, CER, and RQ. This allows researchers to quickly assess microbial growth status and substrate consumption, adjust fermentation control strategies promptly, shorten process development cycles, improve product yields, and reduce batch-to-batch variability.
At the BIOCHINA exhibition, Gaochuan's technical team engaged with numerous technical leaders and procurement personnel from fermentation plants, engineering contractors, research institutes, and synthetic biology companies. They held in-depth discussions on industry hot topics including fermentation scale-up, PAT system implementation, off-gas monitoring solutions, and data application. The team shared practical case studies from various applications and explored future directions for online monitoring technologies in biological fermentation processes.
Keywords：
Process Analytical Technology (PAT)
fermentation off-gas analyzer
BIOCHINA International Exhibition
OUR, CER, and RQ
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